منابع مشابه
Evolution of mutational robustness.
We review recent advances in the understanding of the mutation-selection balance of asexual replicators. For over 30 years, population geneticists thought that an expression derived by Kimura and Maruyama in 1966 fully solved this problem. However, Kimura and Maruyama's result is only correct in the absence of neutral mutations. The inclusion of neutral mutations leads to a wealth of interestin...
متن کاملNeutral evolution of mutational robustness.
We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population's limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network's adjacency matrix. Moreover, the average number of neutral mutant neighbors per individual is given by the mat...
متن کاملDistributed robustness versus redundancy as causes of mutational robustness.
A biological system is robust to mutations if it continues to function after genetic changes in its parts. Such robustness is pervasive on different levels of biological organization, from macromolecules to genetic networks and whole organisms. I here ask which of two possible causes of such robustness are more important on a genome-wide scale, for systems whose parts are genes, such as metabol...
متن کاملMechanisms of mutational robustness in transcriptional regulation
Robustness is the invariance of a phenotype in the face of environmental or genetic change. The phenotypes produced by transcriptional regulatory circuits are gene expression patterns that are to some extent robust to mutations. Here we review several causes of this robustness. They include robustness of individual transcription factor binding sites, homotypic clusters of such sites, redundant ...
متن کاملMutational Robustness and Automatic Program Repair
Mutational robustness describes how likely a variant’s phenotype is to remain constant in response to mutations applied within its genotype. This measure has not been evaluated generally across software, nor more specifically in the context of a genetic programming (GP) approach to automated program repair. We provide an analysis of this metric across eight benchmark programs, representing each...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetic Programming and Evolvable Machines
سال: 2013
ISSN: 1389-2576,1573-7632
DOI: 10.1007/s10710-013-9195-8